Glutathione

Other Research compound (not approved for human use)

Endogenous antioxidant tripeptide (Glu-Cys-Gly) · also known as GSH, L-Glutathione

For reference only — not medical advice. Figures are commonly reported values compiled from published sources and may be wrong or out of date. Many compounds listed are not approved for human use. Talk to a licensed clinician before using any compound.

Glutathione is made in every cell from glutamate, cysteine, and glycine and is central to neutralizing oxidants and processing xenobiotics. It is sold as an oral supplement and as injectable preparations; evidence for what administered glutathione does to body stores varies by route.

Commonly reported dosing (600 mg vial)

Reconstituted with 2 mL → 300 mg/mL.

Phase	Dose	Volume	U-100 units
Starting	100 mg	0.333 mL	33.3
Standard	150 mg	0.5 mL	50
Higher	200 mg	0.667 mL	66.7

Frequency: Once daily or every other day, subcutaneous · Half-life: Short in plasma (minutes) after intravenous administration; subcutaneous data are limited

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Commonly reported reconstitution steps

Vials are usually brought to room temperature (about 15-20 minutes) first.
2 mL of bacteriostatic water is added slowly down the inside wall of the 600 mg vial.
The vial is swirled gently until clear, not shaken.
This gives 300 mg/mL. Mixed vials are typically labeled with the date and refrigerated.

Storage

Before mixing: Lyophilized vials are commonly stored frozen (-20 °C).

After mixing: Reconstituted solution is commonly kept refrigerated (2-8 °C) with freeze-thaw avoided.

Commonly used within 28 days of mixing.

How it works

Reduced glutathione (GSH) donates electrons to detoxify reactive oxygen species and to regenerate other antioxidants, becoming oxidized glutathione (GSSG) in the process, and it conjugates certain toxins for elimination.

Researched for

Studied in an oral supplementation trial for changes in blood and tissue glutathione stores.
Examined in dermatology work on skin pigmentation and aging.
Investigated as a marker and target in aging and oxidative-stress research.

Notes

Category is set to 'other' because glutathione is a general redox metabolite with wide uses, not an aging-specific signal like NAD+.
Pharmaceutical glutathione injections are marketed in some countries outside the US; in the US, injectable products are compounded and not FDA-approved.
Regulators have raised concerns about injectables compounded from non-pharmaceutical-grade glutathione powder.
Dose figures here are community-reported, not derived from a validated subcutaneous trial.