PT-141 + Melanotan II (separate vials)
Stack · 2 separate vials
Also known as Bremelanotide and melanotan II stack
For reference only — not medical advice. Figures are commonly reported values compiled from published sources and may be wrong or out of date. Many compounds listed are not approved for human use. Talk to a licensed clinician before using any compound.
PT-141 and melanotan II, two melanocortin-receptor agonists, reconstituted in separate vials and used on different schedules.
Each 10 mg vial is commonly mixed with 3 mL on its own. PT-141 (bremelanotide) is described as an on-demand compound, whereas melanotan II protocols describe a daily loading phase of several weeks followed by 2-3 times weekly maintenance.
Commonly reported doses per vial
| Peptide | Vial + water | Dose | Volume | U-100 units |
|---|---|---|---|---|
| PT-141 (Bremelanotide) | 10 mg + 3 mL | 1.75 mg | 0.525 mL | 52.5 |
| Melanotan II | 10 mg + 3 mL | 1 mg | 0.3 mL | 30 |
Notes
- PT-141 range reported is 750-1750 mcg; 1.75 mg is the amount in the FDA-approved bremelanotide product, while melanotan II is not approved in the US.
- Melanotan II schedules step up from about 250 mcg toward 1000 mcg over several weeks, then drop to 500-1000 mcg for maintenance.
- Both are melanocortin agonists, so overlapping effects such as nausea and flushing are commonly reported; the combination has no controlled human data.
- Two separate vials, each reconstituted on its own.
Sources
- PubMed — Bremelanotide for HSDD: two randomized phase 3 trials (Obstet Gynecol, 2019)
- DailyMed — Vyleesi (bremelanotide injection) label
- Int J Impot Res — Melanocortin receptor agonists, penile erection and sexual motivation: human studies with Melanotan II
- PeptideDosages.com — PT-141 (10 mg) + Melanotan II (10 mg) stack dosage chart (figures cross-check)
In this stack
PT-141 (Bremelanotide)
Cyclic heptapeptide melanocortin receptor agonist (MC3R/MC4R)PT-141 (bremelanotide) is a melanocortin receptor agonist that is FDA-approved for low sexual desire in premenopausal women.
Melanotan II
Cyclic melanocortin receptor agonist (alpha-MSH analog)Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone that has been studied for skin pigmentation and erectile response.