DSIP

Cognitive Research compound (not approved for human use)

Endogenous neuropeptide (nonapeptide) · also known as Delta Sleep-Inducing Peptide

For reference only — not medical advice. Figures are commonly reported values compiled from published sources and may be wrong or out of date. Many compounds listed are not approved for human use. Talk to a licensed clinician before using any compound.

Delta sleep-inducing peptide was isolated in the 1970s from the cerebral blood of rabbits during induced slow-wave sleep. Despite its name, later work showed its role in sleep is unclear and its effects appear broader, touching stress and circadian-related systems. It has no established receptor and remains a research compound.

Commonly reported dosing (5 mg vial)

Reconstituted with 3 mL → 1.667 mg/mL.

Also sold in 10 mg vials.

Phase	Dose	Volume	U-100 units
Starting	100 mcg	0.06 mL	6
Standard	250 mcg	0.15 mL	15
Higher	500 mcg	0.3 mL	30

Frequency: Once daily in the evening, subcutaneous · Half-life: Very short in plasma (minutes)

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Commonly reported reconstitution steps

Vials are usually brought to room temperature (about 15-20 minutes) first.
3 mL of bacteriostatic water is added slowly down the inside wall of the 5 mg vial.
The vial is swirled gently until clear, not shaken.
This gives 1.67 mg/mL. Mixed vials are typically labeled with the date and refrigerated.

Storage

Before mixing: Lyophilized vials are commonly stored frozen (-20 °C).

After mixing: Reconstituted solution is commonly kept refrigerated (2-8 °C), protected from light, with repeated freeze-thaw avoided.

Commonly used within 28 days of mixing.

How it works

The mechanism is not resolved. Proposed actions include interaction with stress-axis hormones, modulation of neurotransmitter systems, and effects on circadian signaling, but none has been confirmed.

Researched for

Studied in early human sleep studies with mixed and inconsistent results.
Investigated in animal models for stress, seizure, and neuroprotective effects.
Reviewed as a still-unresolved peptide with unclear physiological function.

Notes

The sleep-promoting effect reported in the 1980s literature has not been reliably reproduced.
Reference doses are community-reported rather than from a validated clinical protocol.
Some research used intravenous or intracerebroventricular delivery, which is not covered here.