Pinealon

Bioregulators Research compound (not approved for human use)

Synthetic tripeptide bioregulator (Glu-Asp-Arg) · also known as EDR, Glu-Asp-Arg

For reference only — not medical advice. Figures are commonly reported values compiled from published sources and may be wrong or out of date. Many compounds listed are not approved for human use. Talk to a licensed clinician before using any compound.

Pinealon is among the better-studied peptides in this family, mostly in neuronal cell cultures and rodent models. Reviews also cite small human observations in older adults, but controlled trials of the vial-based format are lacking.

Commonly reported dosing (20 mg vial)

Reconstituted with 3 mL → 6.667 mg/mL.

Phase	Dose	Volume	U-100 units
Starting	1 mg	0.15 mL	15
Standard	1.5 mg	0.225 mL	22.5
Higher	2 mg	0.3 mL	30

Frequency: Once daily, subcutaneous, in 10-20 day courses (community-reported) · Half-life: Not well characterized in the published literature

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Commonly reported reconstitution steps

Vials are usually brought to room temperature (about 15-20 minutes) first.
3 mL of bacteriostatic water is added slowly down the inside wall of the 20 mg vial.
The vial is swirled gently until clear, not shaken.
This gives 6.67 mg/mL. Mixed vials are typically labeled with the date and refrigerated.

Storage

Before mixing: Lyophilized vials are commonly stored frozen (about -20 °C), dry, and protected from light.

After mixing: Reconstituted solution is commonly kept refrigerated (2-8 °C), protected from light, and freeze-thaw cycles are commonly avoided.

How it works

Proposed to enter cells and bind DNA and histones, lowering reactive oxygen species and pro-apoptotic signals (caspase-3, p53) and raising antioxidant enzymes (SOD2, GPX1) in neurons; these mechanisms are hypothesized.

Researched for

Studied in neuronal and PC12 cell cultures for protection against oxidative stress and excitotoxicity.
Examined in rodent models of hypoxia and in aged-rat behavior and neurochemistry.
Investigated in reviews as a candidate regulator of genes involved in Alzheimer's disease pathways.

Notes

Evidence comes largely from a single research group (Khavinson and colleagues, St. Petersburg), mostly cell-culture and animal work; independent replication and controlled human trials are scarce.
Published human work from the originating group has mostly used oral or other non-vial formats; the vial, reconstitution and dosing figures here reflect community-reported conventions rather than trial-validated regimens.
Not FDA-approved.

Sources

Last reviewed 2026-10-06.

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