GHRP-2

Growth hormone axis Research compound (not approved for human use)

Ghrelin-receptor agonist (growth hormone releasing peptide) · also known as Pralmorelin, Growth Hormone Releasing Peptide-2, KP-102

For reference only — not medical advice. Figures are commonly reported values compiled from published sources and may be wrong or out of date. Many compounds listed are not approved for human use. Talk to a licensed clinician before using any compound.

GHRP-2 (pralmorelin) belongs to the first generation of synthetic growth hormone releasing peptides developed in the 1980s-90s. It produces a strong, short-lived GH pulse and has been evaluated as a provocative test for growth hormone deficiency. It is not approved in the US.

Commonly reported dosing (5 mg vial)

Reconstituted with 3 mL → 1.667 mg/mL.

Also sold in 10 mg vials.

Phase	Dose	Volume	U-100 units
Starting	100 mcg	0.06 mL	6
Standard	200 mcg	0.12 mL	12
Higher Optional step reported on the 10 mg vial chart.	300 mcg	0.18 mL	18

Frequency: Once daily (multiple daily doses are also described) · Half-life: ~30-35 minutes (IV, pediatric phase I study)

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Commonly reported dose escalation

Weeks	Dose	Volume	U-100 units
Weeks 1-2	100 mcg	0.06 mL	6
Weeks 3-4	150 mcg	0.09 mL	9
Week 5+	200 mcg	0.12 mL	12

Higher steps may need a larger vial or more than one draw. Escalation schedules vary; dosing decisions belong to a licensed clinician.

Commonly reported reconstitution steps

Vials are usually brought to room temperature (about 15-20 minutes) first.
3 mL of bacteriostatic water is added slowly down the inside wall of the 5 mg vial.
The vial is swirled gently until clear, not shaken.
This gives 1.67 mg/mL. Mixed vials are typically labeled with the date and refrigerated.

Storage

Before mixing: Sealed vials are commonly stored refrigerated (2-8 °C) and protected from light, or frozen for long-term storage.

After mixing: Reconstituted solution is commonly kept refrigerated (2-8 °C), protected from light, and not frozen.

Commonly used within 28 days of mixing.

How it works

GHRP-2 binds the growth hormone secretagogue (ghrelin) receptor at the pituitary and hypothalamus and acts partly through a pathway separate from GHRH, so it can amplify the response to GHRH analogs. It also raises ACTH, cortisol and prolactin to a degree in human studies and increases appetite, as ghrelin does.

Researched for

Evaluated as a diagnostic stimulus for GH deficiency, including in children and adults.
Studied for acute GH, prolactin, ACTH and cortisol responses in healthy volunteers.
Studied for appetite stimulation similar to ghrelin in healthy men.

Notes

Published human work found that the GH response lessened with repeated dosing over several days, which is why frequent dosing is a point of debate.
Reported effects include increased hunger and transient rises in cortisol and prolactin.
Reference charts list both 5 mg and 10 mg vials with the same 3 mL reconstitution; the concentration differs.
Developed as a diagnostic agent in Japan; no US approval.