GHRP-6

Growth hormone axis Research compound (not approved for human use)

Ghrelin-receptor agonist (growth hormone releasing peptide) · also known as Growth Hormone Releasing Peptide-6, Growth Hormone Releasing Hexapeptide

For reference only — not medical advice. Figures are commonly reported values compiled from published sources and may be wrong or out of date. Many compounds listed are not approved for human use. Talk to a licensed clinician before using any compound.

GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) was the first of the synthetic growth hormone releasing peptides, described in the 1980s. It releases GH in humans by several routes, including intravenous, subcutaneous, intranasal and oral administration, and helped lead to the later discovery of ghrelin and its receptor.

Commonly reported dosing (5 mg vial)

Reconstituted with 3 mL → 1.667 mg/mL.

Also sold in 2 mg, 10 mg vials.

Phase	Dose	Volume	U-100 units
Starting	100 mcg	0.06 mL	6
Standard	200 mcg	0.12 mL	12
Higher	300 mcg	0.18 mL	18

Frequency: Up to 3x daily (per injection doses) · Half-life: Short (minutes); limited published pharmacokinetic data

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Commonly reported dose escalation

Weeks	Dose	Volume	U-100 units
Weeks 1-2	100 mcg	0.06 mL	6
Weeks 3-4	200 mcg	0.12 mL	12
Week 5+	300 mcg	0.18 mL	18

Higher steps may need a larger vial or more than one draw. Escalation schedules vary; dosing decisions belong to a licensed clinician.

Commonly reported reconstitution steps

Vials are usually brought to room temperature (about 15-20 minutes) first.
3 mL of bacteriostatic water is added slowly down the inside wall of the 5 mg vial.
The vial is swirled gently until clear, not shaken.
This gives 1.67 mg/mL. Mixed vials are typically labeled with the date and refrigerated.

Storage

Before mixing: Sealed vials are commonly stored refrigerated (2-8 °C) and protected from light, or frozen for long-term storage.

After mixing: Reconstituted solution is commonly kept refrigerated (2-8 °C), protected from light, and not frozen.

Commonly used within 28 days of mixing.

How it works

GHRP-6 activates the growth hormone secretagogue (ghrelin) receptor on pituitary and hypothalamic cells, and works together with GHRH and somatostatin signaling to shape the GH pulse. Ghrelin-receptor activation also drives hunger.

Researched for

Studied for GH-releasing activity in healthy adults, children with short stature and some people with GH deficiency.
Studied for oral and other non-injected routes of GH release.
Investigated in animal models for cytoprotective effects in heart and other tissues.

Notes

Noticeable increases in appetite are commonly reported, more so than with GHRP-2 or ipamorelin; reference charts mention dosing on an empty stomach.
Reference charts list 2 mg, 5 mg and 10 mg vials, all reconstituted with 3 mL.
Clinical data are mostly short-term pharmacology studies; long-term outcomes are not established.